General Information

  • ID:  hor005112
  • Uniprot ID:  P85690
  • Protein name:  Pyrokinin-5
  • Gene name:  NA
  • Organism:  Panesthia sp. (strain BF-2008) (Cockroach)
  • Family:  pyrokinin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  unclassified Panesthia, Panesthia (genus), Panesthiinae (subfamily), Blaberidae (family), Blaberoidea (superfamily), Blattodea (order), Dictyoptera (superorder), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005184 neuropeptide hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  GGETSGEGKGMWFGPRL
  • Length:  17(1-17)
  • Propeptide:  GGETSGEGKGMWFGPRL
  • Signal peptide:  NA
  • Modification:  T17 Leucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Myoactive
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P85690-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P85690-F1.pdbhor005112_AF2.pdbhor005112_ESM.pdb

Physical Information

Mass: 205152 Formula: C77H116N22O24S
Absent amino acids: ACDHINQVY Common amino acids: G
pI: 6.53 Basic residues: 2
Polar residues: 8 Hydrophobic residues: 3
Hydrophobicity: -78.24 Boman Index: -2184
Half-Life / Aliphatic Index: 30 hour Aliphatic Index: 22.94
Instability Index: -662.35 Extinction Coefficient cystines: 5500
Absorbance 280nm: 343.75

Literature

  • PubMed ID:  19257902
  • Title:  A proteomic approach for studying insect phylogeny: CAPA peptides of ancient insect taxa (Dictyoptera, Blattoptera) as a test case.